Tenure Track Professor of Neuronal Energy Metabolism Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging Division of Molecular Biology and Biochemistry Full-time position (100%); initially limited to 6 years, becoming a tenured position when the qualification agreement is met Tenure Track Professor of Neuronal Energy Metabolism Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging Division of Molecular Biology and Biochemistry Full-time position (100%); initially limited to 6 years, becoming a tenured position when the qualification agreement is met We are looking for an excellent researcher with great potential to develop an internationally competitive research agenda in the field of molecular biology and biochemistry. The successful candidate is expected to conduct research and teach in the field of molecular biology and biochemistry with a focus on neuronal energy metabolism. The new position will complement the research activities of the Division of Molecular Biology and Biochemistry at the Gottfried Schatz Research Center Graz. The initial appointment is limited to six years. After the conclusion of a qualification agreement, the career advancement goal is to transfer to a tenured position as an associate professor (tenure track professor pursuant to § 99 para. 5 and 6 of the Universities Act). If the candidate demonstrates outstanding and remarkable achievements, the qualification agreement may be fulfilled more quickly. Core duties and responsibilities:

■ Conducting cutting-edge research in the field of molecular biology and biochemistry with a focus on neuronal energy metabolism and synapse regulation/metabolism

■ Collaborating on related research projects in the division

■ Establishing and leading an internationally recognized research group

■ Teaching undergraduate and graduate courses, supervising diploma and PhD students and mentoring and promoting young researchers

■ Acquiring third-party funding

■ Writing and publishing high-quality scientific papers in reputable journals

■ Establishing and maintaining local, national and international research collaborations

■ Actively participating in the organization and management of the Division of Molecular Biology and Biochemistry including matters related to teaching Successful candidates must have the following qualifications and skills:

◼ PhD or MD/PhD or equivalent doctoral degree in molecular biology/biochemistry or a related field

■ Ability to isolate and culture primary neurons and experience in measuring synaptic vesicle recycling and subcellular metabolism using genetically encoded biosensors

■ Proven track record of high-impact publications and peer-reviewed research grants or other third-party funding as a lead or principal investigator

■ Postdoctoral research fellowship abroad or at a different institution than where the PhD was completed (at least 12 months)

■ High level of proficiency in both written and spoken English (equivalent to proficiency level C1 of the Common European Framework of Reference for Languages) and strong willingness to learn German within 2 years The ideal candidate has the following profile:

■ Experience working with pancreatic beta cells and ability to prepare in situ pancreatic organ slices and to perform microscopic experiments with genetically encoded biosensors

■ Willingness to cooperate on related research projects in the division and ability to work in a team

■ Outstanding level of motivation

■ Systematic and analytical mindset, excellent organizational skills

■ Responsible work habits, resilience and problem-solving skills Application: Med Uni Graz invites all applicants to submit their application online by 25 April 2024. https://www.medunigraz.at/en/job-openings/tenure-track-professorships Statutory information: The minimum remuneration is based on the collective agreement for university employees (KV § 49.2). Scheduled date for job interviews: 10 June 2024 at the Medical University of Graz Contact: This email address is being protected from spambots. You need JavaScript enabled to view it. The Medical University of Graz is committed to increasing the proportion of women in management positions and encourages qualified women to apply. Among applicants with equal qualifications, female applicants will be given priority. We also welcome applications from qualified individuals with disabilities and encourage them to apply

PhD Position

Topic: Investigation of the structure and dynamics of the ghrelin/GHS receptor complex

beginning: at the earliest possible date, payment according to TVL13 (65%)

working group: Prof. Dr. Daniel Huster, Institute of Medical Physics and Biophysics,

                              Härtelstr. 16-18, 04107 Leipzig

The peptide hormone ghrelin plays a key role in food intake and body weight regulation. Ghrelin binds and activates the GHS receptor (GHSR) representing an important pharmacological target. In the project, structural details of the dynamic interaction of ghrelin with GHSR and its conformational dynamics in different states of activation will be studied. We use a combination of experimental methods of nuclear magnetic resonance (NMR) spectroscopy and molecular dynamics (MD) simulation tools in collaboration with projects of the CRC 1423 “Structural Dynamics of GPCR Activation and Signaling”. Alterations of GHSR structure and dynamics, which occur upon binding of the agonist ghrelin, will be studied to address the mechanism of receptor activation and signal transduction to downstream transducer proteins. To understand the high basal activity of GHSR, we will plan to study the loss-of-constitutive-activity Ala204Glu GHSR mutant as downregulation of this basal activity represents a pharmacological goal.

The AG Huster at the Institute of Medical Physics and Biophysics is an international group of ~15 people from different backgrounds. Our values are gender equality, mutual appreciation and support of each other to create a constructive and positive working atmosphere. A video of our group can be found here:

The candidate should hold a master’s degree in biochemistry, chemistry, biophysics or a relevant field.

Applications with a cover letter, a CV, all relevant university certificates and contact information of potential referees should be sent as a single PDF file per email to Daniel Huster, This email address is being protected from spambots. You need JavaScript enabled to view it..

PhD Student or Postdoc (f/m/x) “Theory and Methods for Non-equilibrium Atomistic Simulations of Complex Biomolecules”

YOUNG SCIENTISTS

Job Code: 60-23

Job Offer from December 21, 2023

The Max Planck Institute for Multidisciplinary Sciences is a leading international research institute of exceptional scientific breadth. With more than 40 research groups and some 1,000 employees from over 50 nations, it is the largest institute of the Max Planck Society.

The Department of Theoretical and Computational Biophysics (Prof. Dr. Helmut Grubmüller) is inviting
applications for a

PhD Student or Postdoc (f/m/x)
in the field of
“Theory and Methods for Non-equilibrium Atomistic Simulations of Complex Biomolecules”

Possible projects are variational free energy methods, thermodynamics of solvation shells, Markovian thermodynamics, as well as functional mechanisms of the ribosome, fatty acid synthase, CRISPR/Cas, or intrinsically disordered proteins.

Please indicate in your application which of the above listed projects is most intriguing for you.

Your profile

The successful candidate has a keen interest and strong skills in computational molecular physics and statistical mechanics, and also a great interest in interdisciplinary research and collaboration with experimental groups.

PhD students hold (or expect to complete soon) a Masters or equivalent degree in physics, mathematics or any related field; correspondingly, Postdocs hold a PhD or equivalent degree in the above mentioned fields.

What we offer

• State of the art on-site high performance / GPU compute facilities
• Competitive research in an inspiring, world-class environment
• A wide range of offers to help you balance work and family life
• Further training opportunities and free in-house language courses

The group language is English, so no German language skills are required – but it is a great opportunity for you to learn German! The historic city of Göttingen, located in the heart of Germany, offers great outdoors and cultural opportunities, a vibrant student scene, and an impressive scientific heritage.

Position details

PhD students will have the opportunity to participate in one of several available PhD programs, with three years funding, in collaboration with the University of Göttingen. Masters students aiming at a fast track PhD are also welcome. The Postdoc position is limited to two years with a possibility of extension. Payment and benefits are based on the German Public Service Payscale (TVöD Bund) guidelines. The starting date is flexible.

The Max Planck Society is committed to increasing the number of individuals with disabilities in its workforce and, therefore, encourages applications from such qualified individuals. The Max Planck Society strives for diversity and gender equality and welcomes applications from all backgrounds.

Application

Applications will be reviewed on a rolling basis until the position is filled. Please submit your application including a cover letter (explaining background and motivation), a CV and transcripts (translated to English or German, if applicable) preferably via e-mail and as a single PDF file to:

This email address is being protected from spambots. You need JavaScript enabled to view it.

Max-Planck-Institute for Multidisciplinary Sciences
Department of Theoretical and Computational Biophysics
Prof. Dr. Helmut Grubmüller
Am Faßberg 11
37077 Göttingen
Germany

Social Media: @CompBioPhys

PhD Project ‘Multidimensional in vivo Spectroscopy: Molecular Structure and Dynamics in Complex Biological Reaction Environments’

As part of the Cluster of Excellence ‘Unifying Systems in Catalysis’ (UniSysCat), the Horch research group ‘Ultrafast Dynamics in Catalysis’ aims to understand complex catalytic systems and superordinate reaction networks by using an integrated approach of advanced spectroscopic and theoretical methods. In particular, we are interested in metalloenzymes – huge metal-containing proteins that catalyse, e.g., the conversion of small molecules like H₂ and CO₂.

More details about the Horch research group and UniSysCat, can be found here:

https://www.physik.fu-berlin.de/en/einrichtungen/ag/ag-horch/

https://www.unisyscat.de/people/current-group-leaders/horch-marius/

Project Description

To establish a “greener” chemistry based on living cells, we envisage the design of a cellular system that uses waste material and unlimited sun light for sustainable hydrogen production. Developing such a system requires a detailed understanding of all involved processes on the molecular and cellular level. Together with multiple partners, the successful candidate will develop a multichannel in vivo spectroscopy approach to target the involved biological macromolecules, relevant cytoplasmic factors, and the interplay of these two types of cellular key determinants. Focusing on the hydrogen-producing enzyme, a [NiFe] hydrogenase, this strategy will expand previously established in vivo spectroscopic strategies by introducing ultrafast and multidimensional infrared techniques that yield details insights into structure, dynamics, and environmental interactions. In total, this approach will provide a guideline for the rational design of cellular catalytic systems.

Relevant Publications

https://doi.org/10.1002/anie.201002197

https://doi.org/10.1039/C5CP02447A

https://doi.org/10.1039/C9SC02851J

Field of Work

- Ultrafast nonlinear infrared spectroscopic experiments (2D-IR and IR-IR pump-probe)

- Execution of such experiments at international research facilities

- Analysis and interpretation of spectroscopic data

- Interdisciplinary cooperation with other members of the overarching team project

- Manipulation and handling of delicate biological samples supplied by collaboration partners

- If beneficial, calculation of infrared spectroscopic observables by quantum chemical methods

- Writing of scientific articles for publication in international peer-reviewed journals

- Presentation of research results at international scientific conferences

We Offer

We offer a position in an exciting and challenging project with the opportunity to obtain a PhD. The project will be pursued in a dynamic, international, and cooperative team of scientists from different fields of research. The project is also part of UniSysCat, which provides the opportunity to engage in interdisciplinary collaborations and build scientific networks. As a first-class location for science and a vibrant global city, Berlin offers an ideal framework.

Requirements

Master’s degree (or equivalent) in the field of physics, physical chemistry, biophysics or similar

Desirable Qualification

Expertise and experience in the following areas is desirable, but knowledge in all them of them is not mandatory. Applications from candidates that are willing to learn about the listed aspects are welcome

- Excellent university degree

- Experience with infrared spectroscopy or vibrational spectroscopy in general

- Experience with ultrafast nonlinear spectroscopy and data analysis

- Experience with (pulsed) laser sources and (nonlinear) optics

- Experience with quantum chemical calculations

- Experience with the handling of biological and/or oxygen-sensitive samples 

- Knowledge in biological, inorganic, and/or photo chemistry

- Programming skills, preferably in Python

- Ability to work independently and as part of an interdisciplinary team

- Creativity, enthusiasm, and a genuine interest in the advertised project

- Fluency in English (spoken and written)

Starting Date

As soon as possible

Application Deadline

13 March 2023. Applications sent after the deadline will be considered until the position is filled.

Funding

TV-L E13 (67 %) until 31 December 2025, funding by the DFG via UniSysCat, funding extension from other sources is possible

Selection Process

Please send your documents and requests to Dr. Marius Horch (This email address is being protected from spambots. You need JavaScript enabled to view it.)

Further details can be found here:

https://www.fu-berlin.de/universitaet/beruf-karriere/jobs/english/PH-Horch-UniSysCat-Cells-2023-E.html